What’s in Your Genes?

We have all heard people say that a newborn baby has his mother’s eyes, or that a young child gets all of that curly hair from her father’s side of the family, or that a rapidly growing teen gets his height from his grandfather’s side of the family. These simple observations are based on the fact that genetics play a major role in determining our physical features. As the mysteries of the human genome are unraveled, we can peer beyond physical traits and discover there are many variables to understanding the full impact that genetics plays. As a Fitdigits user, one question that may intrigue you is, “what degree does genetics play in the pursuit of improving overall health or increasing fitness levels?”

Fifty years ago the Sports Medicine community was satisfied with describing the human physique according to three categories of body types: endomorph, mesomorph and ectomorph. Later on, primary care physicians began to associate and describe the increased risk of developing heart disease in terms of body shape; i.e. apple shaped for men and pear shaped for women.

Today’s medical technology allows us to look further into the human body to the point where we can actually compare and contrast factors, such as quantity of fat cells, muscle fiber type, heart size, bone density, cardiac output, muscle mitochondria, and even the risk of contracting disease. The ability to measure these more specific variables and potential based upon genetics is important, because they give insight into the body’s ability to adapt and benefit from different interventions and treatment programs.

The key to designing an exercise program is to help the body adapt to a specific stimulus – in other words, to achieve a specific training effect.

Over the following weeks I’ll explore Cardiovascular Fitness, Body Composition (% body fat), and Disease Prevention, in ways that provide insight into the role genetics play. Your genetic profile can be an important guide in the successful pursuit of improving your overall health or increasing your level of fitness. First up, Cardiovascular Fitness.


An individual’s ability to perform aerobic exercises like running, cycling, swimming or cross country skiing is ultimately determined by the heart’s capacity to deliver oxygen to the specific muscle groups engaged in each sport, as well as the muscle’s ability to convert oxygen and available fuel (food) into energy. Cardiovascular fitness can be measured through an Oxygen Consumption or VO2 test. An athlete wears a facemask over his mouth and nose while running or cycling at increasing levels of intensity. The mask is connected to a computer that is able to compare the difference between the amount of oxygen inhaled and exhaled with each breath. The key finding behind VO2 testing is that VO2 scores are linear with performance. In other words, athletes with higher VO2 scores have been shown to run, swim, ski and bike faster and longer than athletes with lower scores.

Dan Zeman with Greg LeMond, three-time winner of the Tour de France, testing VO2 levels to monitor and maximize training effect.

Dan Zeman with Greg LeMond, three-time winner of the Tour de France, testing VO2 levels to monitor and maximize training effect.

VO2 scores in the general population range from 20 – 60 ml/kg/min, follow a bell shaped curve across the range of scores, are slightly higher in males, tend to decrease with aging, and increase when the subject maintains a structured exercise program. However, the most interesting observations are that people DO NOT respond the same way to the same training program, and world-class level endurance athletes’ VO2 scores are much higher, in the 80-95 ml/kg/min range.

Elite athletes DO NOT have higher maximal heart rates than those whose VO2 scores are lower, but they DO differ in how their hearts adapt to training, allowing more blood pumped per beat. They also differ in how the mitochondria in their muscles adapt, resulting in a higher capacity to convert oxygen and fuel into energy. These observations are valuable, because they indicate a genetic component is at work in the adaptation to cardiovascular exercise.

Consider the “sport of choice” of an Olympic Track and Field athlete. Each event has a gold medal winner who most likely realized at an early stage of training that he/she had a natural inclination to performing well in that particular event. One size does not fit all, and even Olympic athletes don’t adapt the same way to a specific training program. Some athletes are genetically gifted for short distances, while others are gifted for long distances. This doesn’t mean athletes can’t train for other events and do well; it just means they start off with a set of genetic gifts that may allow them to perform better in one event over another.

The general population can benefit from this concept. Let’s use an example. If you’re in reasonably good shape and contemplating running a marathon, but you find that you can only handle a slow pace when you train, this could be an insight into your genetic make-up. Genetically speaking, the best distance for you might be a 5-10k. You may actually enjoy a faster paced 5-10K over a long distance marathon, because your body is genetically built for shorter, faster distances. This is not to discourage anyone from running a marathon if that’s a personal goal. I’m just trying to point out that you may find that you actually enjoy one distance over another, discover that you perform better with certain distances, and perhaps experience fewer injuries with your “sport of choice.”

In addition, most of us can benefit from a seasonal approach to training. Even elite athletes train with awareness of their genetic predisposition, knowing that the risk of sustaining an overuse injury is higher when training for a world record. They realize their peak performance and condition can only last for a limited amount of time. Variables such as maintaining an ideal race body weight, adequate rest, meticulous control of calories, and limiting the number of race days allows them to stay in world record shape for race day, ready for show time.

The body also needs to rest. Without a legitimate off-season, the human body will begin to shows signs of muscular skeletal stress fractures, decrease in positive psychological mood states, poor sleep habits, weight gain, and finally a measurable drop in cardiovascular fitness or VO2 scores.

This brings us back to the best questions to ask first: why am I doing cardiovascular exercise, what particular exercise best suits me, and how much is best for me?

My best answer is also the simplest: choose a form of exercise that you find enjoyable, and choose a duration and intensity that allows you to speak a single sentence clearly and without hesitation during the exercise. It’s simply a “talk test.” See if you can talk easily while you’re walking, running, cycling or engaging in any cardiovascular exercise. I also encourage a variety of forms of cardiovascular exercise, and whenever possible, combine them with a social or personal agenda.

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Fitdigits Helps Anthony Be Heart Smart

Testimonial by Fitdigits User Anthony D.

When I was a child, I was diagnosed with Bicuspid Aortic Valve, which means that my aortic valve has only two leaflets that open and close. Normal aortic valves have three leaflets, and because of my deformity, blood leaks back into the heart during each pump cycle. As a kid, this was no big deal. My doctors told me that I wouldn’t need heart surgery until I was close to 60 years old, and by the time that happens, robots with lasers will do the surgery and I’ll be out running marathons the next day!

I lived my life without fear of my heart disease. I became very active. I got really into rock climbing. I cycle four times a week. I went backpacking and on other adventures, often very physically demanding on the body. A day without some sort of exercise is rare in my life.

Fast forward to 2011. I’m 28 years old and after a career change, just landed my first teaching job, 8th grade science. With my new health insurance plan, I decided to establish a new primary physician and cardiologist. My cardiologist did the routine checks, most importantly the echocardiogram (a sonogram for the heart). She handed me a piece of paper with a flow chart on it. She circled a spot on the confusing lines and said that someday, soon, I would need heart surgery. “Like ten to twenty years?” I asked. “One to two,” she said, “five at most.” I was shocked. I didn’t believe her.

Fast forward to present day. After two years of bi-annual visits to the echocardiogram technician, on a whim, my cardiologist scheduled a CT scan of my chest. This revealed an Ascending Aortic Aneurysm, a condition common to people with valve problems, where the aorta artery balloons as it exits the heart. The risk: rupture and sudden death. I’m thirty years old and I need open heart surgery.

My surgeon told me that in the meantime, to keep my heart rate under 140/150 BPM. I imagined that with the way I tend to push myself, this would be a difficult task. I immediately purchased a heart rate monitor that connects to my IPhone via Bluetooth. I downloaded over 5 apps, including Fitdigits. I even paid for trial versions on 3 of them. After 2 days, I knew Fitdigits was the right one for me.

Right off the bat, I liked Fitdigits’s look and appearance. Crisp and simple, with bold colors. Most importantly, and the reason I chose Fitdigits over the others, is the ability to customize preferences to you. Because I need to keep my heart rate low, I could create my own heart rate zones, and set the voice feedback to notify me when I enter those zones. The Fitdigits voice tells me when I start to approach 140 BPM, and when I go over my prescribed max, a get a warning. Using these features, I have been able to continue cycling; even going for nice long rides over thirty miles. I have been able to continue rock climbing, though not necessarily as hard as before, I am so thankful that I don’t have to give it up.

Anthony’s Heart Rate Chart

For cycling, I love how Fitdigits displays a line graph that charts heart rate, speed, and elevation. I can see what situations make my heart rate spike, so that I can plan my attack better to avoid those spikes. Another function that I appreciate is a pie graph that displays the time in each zone. I know that I’m doing what I’m supposed to when my results show less than 2% spent in the zones over 150 BPM. Not only has Fitdigits allowing me to continue exercise, but also after my surgery in November, and months of recovery, Fitdigits will teach me how to be a better athlete. Having control over one’s heart rate is important for any athlete, and in my case it is paramount. So far, Fitdigits has taught me how to be more a more efficient athlete. I plan to be a better climber and cyclist this time next year, less than a year after heart surgery.

Fitdigits has supplied me with a service that is invaluable. I would surely recommend Fitdigits to any athlete of any level, in a heartbeat (pun intended). Fitdigits has allowed me to stay strong, which will inevitably be beneficial to the recovery process ahead.

Read more about Anthony’s Heart Valve Replacement Saga on his blog, http://robovalve.wordpress.com/